Nathanael Greene Middle School serves approximately 1,000 general education students and English learners in grades 6-8, with each grade divided into smaller learning communities named after local colleges and universities. The school employs an advisory model to offer personalized learning experiences geared toward college and career readiness in grades 6-8. Additionally, the school offers an Advanced Academics program; admission to the program is on an application basis. Greene hosts a number of after-school programs and an emerging CTE/STEM program with a focus in technology, computer science and robotics. Greene has a Dean of school culture to help liaise between the community and students. Special education inclusion, self-contained and self-contained hybrid programs are offered.